Scans using PET revealed hemispheric differences in brain glucose consumption when scans with and without diazepam were compared. Scans using SPECT revealed unihemispheric blood flow reduction following diazepam doses greater than 0.55 mg kg -1 for these 180-200 kg animals. MRIs were used to register functional brain scans with single photon emission computed tomography (SPECT)and positron emission tomography (PET) in trained dolphins. Diazepam has been shown to induce unihemispheric slow waves (USW), therefore we used functional imaging of dolphins with and without diazepam to observe hemispheric differences in brain metabolism and blood flow. This report documents the first use of magnetic resonance images (MRIs) of living dolphins to register functional brain scans, allowing for the exploration of potential mechanisms of unihemispheric sleep.
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